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Owing to important biological activities, the synthesis of heterocyclic compounds has drawn significant attention from the viewpoint of organic chemist. Selective C–C bond formation or C–X (X = heteroatom) bond formation reactions have been widely used to construct the core of heterocyclic systems. Transition-metal-catalyzed cross coupling reactions have been recently identified as the most versatile and useful methods to form new C–C bonds. Popular cross-coupling reactions required toxic transition metals, pre-functionalized substrates like air-sensitive organometallic reagents and an activated coupling partner. As a consequence, cross-coupling reactions are known to produce undesired toxic side products and heavy metal waste.
Research in the Maiti laboratory was focused on direct functionalization of non-activated C–H bonds to construct a selective C–C bond. This is a convenient and powerful alternative to cross-coupling. We have developed a library of transition-metal-catalyzed intra- and intermolecular reactions to construct a particular heterocyclic core based on C–H activation.
Agasti, S.; Pal, T.; Achar, T. K.; Maiti, S.; Pal, D.; Mandal, S.; Daud, K.; Lahiri, G. K.; Maiti, D.
Angew. Chem. Int. Ed. 2019, 58, 11039 (VIP Paper)
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