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Tandem Dehydrogenation-Olefination-Decarboxylation of Cycloalkyl Carboxylic Acids via Multifold C-H Activation


Pal, T.; Ghosh, P.; Islam, M., Guin, S.; Maji, S.; Dutta, S.; Das, J.; Ge, H.; Maiti, D.

Nat. Commun., 2024, (ASAP)





Enantiodivergent synthesis of isoindolones catalysed by a Rh(III)-based artificial metalloenzyme


Mukherjee, P.;† Sairaman, A.;† Deka, H. J.; Jain, S.; Mishra, S. K.; Roy, S.; Bhaumik, P.; Maiti, D.

 Nat. Synth., 2024, (ASAP)





       Surpassing the Limited Coordination Affinity of Native Amides by Introducing Pyridone-Pd-AgOAc Cluster                   to Promote Distal γ-C(sp3)-H Arylation


        Goswami, N.; Kumar, N.; Gupta, P.; Maiti, D.

        ACS Catal. 2024, 14, 3798–3811





   Mizoroki–Heck-type transformations in natural product synthesis: case studies in carbopalladation and forging               all-carbon quaternary stereocenters

    Fuller, R. O.; Maiti, D.; Bissember, A. C.

    Chem Catal., 2024, 100921




        Harnessing the “Methyl Effect” in the Development of Novel Meta-directing Template for C–H Cyanation 


        Bhattacharya, T.;† Teja, C.;† Kumar, N.; Bhagat, K. K.; Lahiri, G. K.; Gupta, P.; Tyagi, S.; Maiti, D.

        ACS Catal. 2024, 14, 2216-2228




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Light-induced Pd catalyst enables C(sp2)–C(sp2) cross-electrophile coupling bypassing the demand for transmetalation


 Maiti, S.;  Ghosh, P.; Raja, D. K.; Ghosh, S.; Chatterjee, S.; Sankar, V.; Roy, S.; Lahiri, G. K.; Maiti, D.

 Nat. Catal., 2024, 7, 285




Nat Cat.PNG

    Highly scalable photoinduced synthesis of silanols via untraversed pathway for chlorine radical (Cl•) generation


    Saha, A.; Ali, W.; Werz, D. B.; Maiti, D.

    Nat. Commun., 2023,14, 8173





  Combinatorial Ligand Assisted Simultaneous Control of Axial and Central Chirality in Highly Stereoselective              C-H Allylation  


   Bhattacharya, T.; Ghosh, S.; Dutta, S.; Guin, S.; Ghosh, A.; Ge, H.; Sunoj, R. B.; Maiti, D.

   Angew. Chem. Int. Ed. 2024, 63,  e20231011




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        Photoinduced [3+2] Cycloaddition of Carbenes and Nitriles: A Versatile Approach to Oxazole Synthesis


        Saha, A.; Sen, C.; Guin, S.; Das, C.; Maiti, D.; Sen, S.; Maiti, D.

        Angew. Chem. Int. Ed, 2023,62,  e20230891

        Highlighted in ChemistryViews, Highlighted in Org. Process Res. Dev., Highlighted in Synfacts





    Unveiling catalyst-free electro-photochemical reactivity of aryl diazoesters and facile synthesis of oxazoles,               imide-fused pyrroles and tetrahydro-epoxy-pyridines via carbene radical anion


    Maiti, D.; Saha, A.; Guin, S.; Maiti, D.; Sen, S.

    Chem. Sci., 202314, 6216





       Non-Directed C-H/C-F Coupling for the Synthesis of α-Fluoro Olefinated Arenes  


        Porey, S.; Bairagi, Y.; Guin, S.; Zhang, X.; Maiti, D.

        ACS Catal. 2023, 13, 14000–14011




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    Energy-efficient CO2/CO interconversion by homogeneous copper-based molecular catalysts 


    Guria, S.; Dolui, D.; Das, C.; Ghorai, S.; Vishal, V.; Maiti, D.; Lahiri, G. K.; Dutta, A.

    Nat. Commun., 2023,14, 6859





Transition-metal catalyzed C‒H activation as a means of synthesizing complex natural products


Sinha, S. K.; Ghosh, P.; Jain, S.; Maiti, S.; Al-Thabati, S. A.; Alshehri, A. A.; Mokhtar, M.; Maiti, D.

Chem. Soc. Rev., 2023, 52, 7461-7503





   Directing Group Assisted para-Selective C-H Alkynylation of Unbiased Arenes Enabled by Rhodium Catalysis


    Dutta, U.; Prakash, G.; Devi, K.; Borah, K.; Zhang, X.; Maiti, D.

    Chem. Sci., 202314, 11381





Deciphering the Mechanistic Insights of Temporary Directing Group Assisted meta-Alkenylation of Complex Biaryl Systems


 Goswami, N.;† Kumar, N.;† Bag, S.; Gupta, P.; Maiti, D.

 ACS Catal., 2023, 13, 11091





    Access to Unsaturated Bicyclic Lactones by Overriding Conventional C(sp3)-H Site Selectivity


    Das, J.; Ali, W.; Ghosh, A.;† Pal, T.;† Mandal, A.;† Teja, C.; Dutta, S.; Pothikumar, R.; Ge, H.; Zhang, X.; Maiti, D.

    Nat. Chem., 2023, 15, 1626

    Nature Blog

    Highlighted in Research Matters, Selected as Synfact of the Month Feb'24 

    Covered in the April issue of Synform





 Simplifying the Synthesis of Non-proteinogenic Amino Acids via Palladium Catalysed (delta)-Methyl C-H               Olefination of Aliphatic Amines and Amino Acids 

    Bhattacharya, T.; Baroliya, P. K.; Al-Thabaiti, S. A.; Maiti, D.

     JACS Au, 2023, 3, 1975



   Photoinduced meta-Selective C-H Oxygenation of Arenes

    Ali, W.;† Saha, A.;† Ge, H.; Maiti, D.

    JACS Au, 2023, 3, 1790




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    Site-Selective C–H Functionalization of Carbazoles

    Elsaid, M.‡ Ge, R.‡ Liu, C. Maiti, D.* and Ge, H.*

    Angew. Chem. Int. Ed, 2023,62, e202303110




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    Enroute Sustainability: Metal Free C-H bond Functionalisation


    Roy, S.; Panja, S.; Sahoo, S. R.; Chatterjee, S.; Maiti, D.

    Chem. Soc. Rev., 2023, 52, 2391-2479





    Distal meta-alkenylation of formal amines enabled by catalytic use of hydrogen-bonding anionic ligands


    Goswami, N.;† Sinha, S. K.;† Mondal, P.; Adhya, S.; Datta, A.; Maiti, D.

    Chem, 2023, 9, 989-1003





    Photo-Excited Nickel-Catalyzed Silyl-Radical-Mediated Direct Activation of Carbamoyl Chlorides To Access                  (Hetero)aryl Carbamides


    Maiti, S.;† Roy, S.;† Ghosh, P.; Kasera, A.; Maiti, D.

    Angew. Chem. Int. Ed., 2022, 61, e202207472





   Substrate-Rhodium Cooperativity in Photoinduced ortho-Alkynylation of Arenes


    Saha, A.; Ghosh, A.; Guin, S.; Panda, S.; Mal, D. K.; Majumdar, A.; Akita, M.; Maiti, D.

    Angew. Chem. Int. Ed., 2022, 61, e202210492





   Pd Catalyzed Dual-γ-1,1-C(sp3)-H Activation of Free Aliphatic Acids With Allyl-O Moieties


    Das, J.; Pal, T.; Ali, W.; Sahoo, S. R.; Maiti, D.

    ACS Catal., 2022, 12, 11169-11176





   Non-Directed Pd-Catalysed Electrooxidative Olefination of Arenes


    Panja, S.; Ahsan, S.; Pal, T.; Kolb, S.; Ali, W.; Sharma, S.; Das, C.; Grover, J.; Dutta, A.; Werz, D. B.; Paul, A.; Maiti, D.

    Chem. Sci., 2022, 13, 9432-9439




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   Transition-Metal-Catalyzed C−H Bond Alkylation Using Olefins: Recent Advances and Mechanistic Aspects


    Mandal, D.; Roychowdhury, S.; Biswas, J. P.; Maiti, S.; Maiti, D.

    Chem. Soc. Rev., 2022, 51, 7358-7426




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   Expanding chemical space by para-C-H arylation of arenes 


    Maiti, S.; Li, Y.; Sasmal, S.; Guin, S.; Bhattacharya, T.; Lahiri, G. K.; Paton, R. S.; Maiti, D.

    Nat. Commun., 2022,13, 3963





    Dual Ligand Enabled Non-Directed C−H Chalcogenation of Arenes and Heteroarenes 


    Sinha, S. K.;† Panja, S.;† Grover, J.;† Hazra, P. S.; Pandit, S.; Bairagi, Y.; Zhang, X.; Maiti, D.

    J. Am. Chem. Soc., 2022,144, 12032-12042




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   Ligand-promoted palladium-catalyzed β-methylene C−H arylation of primary aldehydes


    Yang, K.; Li, Z.; Liu, C.; Li, Y.; Hu, Q.; Elsaid, M.; Li, B.; Das, J.; Dang, Y.; Maiti, D.; Ge, H.

    Chem. Sci., 2022,13, 5938-5943




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   Directing Group Assisted Rhodium Catalyzed meta-C-H Alkynylation of Arenes


    Sasmal, S.;† Prakash, G.;† Dutta, U.;† Laskar, R.; Lahiri, G. K.; Maiti, D.

    Chem. Sci., 2022, 13, 5616-5621




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   C-H deuteration of organic compounds and potential drug candidates 


    Prakash, G.; Paul, N.; Oliver, G. A.; Werz, D. B..; Maiti, D.

    Chem. Soc. Rev., 2022, 51,3123-3163




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   Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites


    Saha, A.;† Guin, S.;† Ali, W.; Bhattacharya, T.; Sasmal, S.; Goswami, N.; Prakash, G.; Sinha, S. K.; Chandrashekar, H. B.;              Panda, S.; Anjana, S. S.; Maiti, D.

    J. Am. Chem. Soc., 2022, 144, 1929 , Highlighted in "Synfacts"





   Emergence of Pyrimidine as meta-Directing Group: Journey from Weak to Strong Coordination in                                   Diversifying meta-C−H Functionalization


    Dutta, U.; Maiti, D.

    Acc. Chem. Res​., 202255, 354





   Ligand-redox assisted nickel catalysis toward stereoselective synthesis of (n+1)-membered cycloalkanes                     from 1,n-diols with methyl ketones


    Bains, A. K.; Kundu, A.; Maiti, D.; Adhikari, D.

    Chem. Sci., 2021, 12, 14217




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   Toolbox for Distal C-H Bond Functionalizations in Organic Molecules


    Sinha, S. K.; Guin, S.; Maiti, S.; Biswas, J. P.; Porey, S.; Maiti, D.

    Chem. Rev., 2022122, 5682




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   Ligand Enabled delta-C(sp3)-H Borylation of Aliphatic Amines 


     H. B. Chandrashekar, Dolui. P.; Li, B.; Mandal, A.; Liu, H; Guin, S; Ge, H; Maiti, D.

     Angew. Chem. Int. Ed., 2021, 60, 18194 (Appears in Hot Topic: C-H Activation)




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    Effect of ligand backbone on the reactivity and mechanistic paradigm of non-heme iron(IV)-oxo during                        olefin epoxidation 


     Biswas, J. P.; Ansari, M.; Paik, A.; Sasmal, S; Paul, S; Rana, S; Rajaraman, G.; Maiti, D.

     Angew. Chem. Int. Ed. 2021, 60, 14030





  Arene Diversification via Distal C(sp2)-H Functionalization 


     Dutta, U.; Maiti, S.; Bhattacharya, T.; Maiti, D.

     Science, 2021, 372, 701





  Hexafluoroisopropanol: The Magical Solvent for Pd-Catalyzed C-H Activation


    Bhattacharya, T.; Ghosh, A.; Maiti, D.

    Chem. Sci., 2021, 12, 3857





   Recent development in transition metal-catalyzed C-H olefination


    Ali, W.; Prakash, G.; Maiti, D.

    Chem. Sci., 2021, 12, 2735





         Imine as a linchpin approach for meta-C–H functionalization


          Bag, S.; Jana, S.; Pradhan, S.; Bhowmick, S.; Goswami, N.; Sinha, S. K.; Maiti, D. 

          Nat. Commun. 2021, 12, 1393




     Transition Metal Catalyzed C-H Allylation Reactions


     Dutta, S.; Bhattacharya, T.; Werz, D. B.; Maiti, D.

     Chem.2020,7, 555  




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  Organic synthesis with the most abundant transition metal- Iron: From rust to multitasking catalysts


    Rana, S.; Biswas, J. P.; Paul, S.; Paik, A.;  Maiti, D.

    Chem. Soc. Rev., 2020, 50, 243





  Diverse Strategies for Transition Metal Catalyzed Distal C(sp3)-H Functionalizations


    Das, J.; Guin, S.; Maiti, D.

    Chem. Sci., 2020, 11, 10887





   A Direct Route to Six and Seven Membered Lactones via γ-C(sp3)-H Activation: A Simple Protocol to Build                     Molecular Complexity


     Das, J.; Dolui, P.; Ali, W.; Biswas, J. P.; Chandrashekar, H. B.; Prakash, G; Maiti, D.

     Chem. Sci202011, 9697




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 Para-Selective Arylation of Arenes: A Direct Route to Biaryls by Norbornene Relay Palladation  


     Dutta, U.; Porey, S.; Pimparkar, S.; Mandal, A; Grover, J; Koodan, A; Maiti, D.

     Angew. Chem. Int. Ed. 2020, 59, 20831





 Palladium-catalyzed meta-C–H allylation of arenes: A unique combination of pyrimidine-based template and             hexafluoroisopropanol


     Bag, S.; K, S.; Mondal, A.; Jayarajan, R.; Dutta, U.; Porey, S.; Sunoj, R. B.; Maiti. D.

    J. Am. Chem. Soc, 2020, 142, 12453





 An Alkyne Linchpin Strategy for Drug:Pharmacophore Conjugation: Experimental and Computational Realization of a meta-selective Inverse Sonogashira Coupling


     Porey, S.; Zhang, X.; Bhowmick, S.; Singh, V. K.; Guin, S.; Paton, R. S.; Maiti. D.

     J. Am. Chem. Soc, 2020, 142, 3762-3774  (This paper appears in synfacts contribution)

     (selected in "JACS Early Career Investigators" virtual issue)





Ligand-Enabled Pd(II)-Catalyzed Iterative γ-C(sp3)-H Arylation of Free Aliphatic Acid


     Dolui, P.; Das, J.; Chandrashekar, H. B.; Anjana, S. S.; Maiti, D.

     Angew. Chem. Int. Ed. 2019, 58, 13773-13777




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 Co‐ordination assisted distal C−H alkylation of fused heterocycles


     Kankanala, R.; Biswas, J. P.; Jana, S.; Achar, T. K.; Porey, S.; Maiti, D.

     Angew. Chem. Int. Ed. 2019, 131, 13946-13950





 Rhodium Catalyzed Template-Assisted Distal para-C-H Olefination


      Dutta, U.; Maiti, S.; Pimparkar, S.; Maiti, S.; Gahan, L. R.; Krenske, E. H.; Lupton, D. W.; Maiti, D.   

      Chem. Sci. 2019,10, 7426-7432



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 Regioselective Synthesis of Fused Furans by Decarboxylative Annulation of α,β-Alkenyl Carboxylic Acid with   Cyclic Ketone: Synthesis of Di-heteroaryl Derivatives


     Agasti, S.; Pal, T.; Achar, T. K.; Maiti, S.; Pal, D.; Mandal, S.; Daud, K.; Lahiri, G. K.; Maiti, D.

     Angew. Chem. Int. Ed. 2019, 58, 11039-11043 (VIP Paper)




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   Palladium-Catalyzed Directed meta-Selective C-H Allylation of Arenes: Unactivated Internal Olefins as Allyl               Surrogates


     Achar, T. K.; Zhang, X.; Mondal, R.; Shavanas, M. S.; Maiti, S.; Maity, S.; Pal, N.; Paton, R. S.; Maiti, D.

     Angew. Chem. Int. Ed. 2019, 58, 10353-10360 




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Iterative Arylation of Amino Acids and Aliphatic Amines via-C(sp3)-H Activation: Experimental and Computational Exploration


     Guin, S.; Dolui, P.; Zhang, X.; Paul, S.; Singh, V. K; Pradhan, S.; Chandrashekar, H. B.; S. S. Anjana.; Paton, R. S.; Maiti, D.

     Angew. Chem. Int. Ed 2019, 58, 5633-5638 





         Game of Directors: Accessing Remote Meta- and Para-C-H Bonds With Covalently Attached Directing Groups


              Dey, A.; Sinha, S. K.; Achar, T. K.; Maiti, D.

              Angew. Chem.Int. Ed 2018, 58, 10820-10843





         Selective C-H Halogenation over Hydroxylation by Non-heme Iron(IV)-oxo


           Rana, S.; Biswas, J. P; Sen, A.; Clemency, M.; Blondin, G.; Latour, J-M.; Rajaraman, G.; Maiti, D.   

           Chem.Sci 2018, 9, 7843-7858




          H-Bonded Template Assisted Para Selective Carboalkylation Using Soft Electrophilic Vinyl Ether


           Maji, A.; Dahiya, A.; Lu, G.; Bhattacharya, T.; Liu, P.; Zanoni, G.; Maiti, D. 

            Nat Commun 2018, DOI: 10.1038/s41467-018-06018-2 




 Diverse Meta-C-H Functionalization of Arenes Across Different Linker Lengths


  Jayarajan, R.; Das, J.; Bag, S.; Choudhury, R.; Maiti, D. 

   Angew. Chem. Int. Ed. 2018, 57, 7659 –7663


   Experimental and Computational Exploration of para-Selective Silylation with a Hydrogen-Bonded Template

    Maji, A.; Guin, S.; Feng, S.; Dahiya, A.; Singh, V. K.; Liu, P.; Maiti, D.

    Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201708449

  Remote meta-C–H cyanation of arenes enabled by pyrimidine-based auxiliary


    Bag, S.; Jayarajan, R.; Dutta, U.; Chowdhury, R.; Mondal, R.; Maiti, D.
     Angew. Chem. Int. Ed. 2017, 56, 12538-12542

 Introducing Unactivated Acyclic Internal Aliphatic Olefins in Cobalt Catalyzed Allylic Selective Dehydrogenative Heck                 Reaction


    Maity, S.; Dolui, P; Kancherla, R.; Maiti, D. 

    Chem. Sci. 2017, 8, 5181-5185

  XPhos Ligated Rhodium Catalyzed meta C–H Functionalization of Arenes


      Bera, M.; Agasti, S.; Chowdhury, R.; Mondal, R.; Pal, D.; Maiti, D.

      Angew. Chem. Int. Ed. 2017, 56, 5272-5276

  Template-assisted meta-C–H alkylation and alkenylation of arenes


     Bag, S.; Jayarajan, R.; Mondal, R.; Maiti, D.

     Angew. Chem. Int. Ed. 2017, 56, 3182-3186

  Detailed Mechanistic Studies on Palladium Catalyzed Selective C-H Olefination with Aliphatic Alkenes: A Significant                    Influence of Proton Shuttling


      Deb, A.; Hazra, A.; Peng, Q.; Paton, R. S.; Maiti, D.

      J. Am. Chem. Soc. 201739, 763-775

  Copper/P(t-Bu)3-Mediated Regiospecific Synthesis of Fused Furans and Naphthofurans


       Naveen, T.; Deb, A.; Maiti, D.

       Angew. Chem. Int. Ed. 2017, 129, 1111-1135

 Cobalt Catalyzed sp2-C-H Activation and Intermolecular Heterocyclization with Allenes at Room Temprature 


      Thrimurtulu, N.; Dey, A.; Maiti, D.; Volla, C. M. R.

      Angew. Chem. Int. Ed. 201655, 12361-12365

 Palladium-Catalyzed Directed para C-H Functionalization of Phenols


     Patra, T.; Bag, S.; Kancherla, R.; Mondal, A.; Dey, A.; Pimparkar, S.; Agasti,         S.; Modak, A.; Maiti, D.

     Angew. Chem. Int. Ed. 201655, 7751-7755

 Directing group assisted meta-hydroxylation by C-H activation


    Maji, A.; Bhaskararao, B.; Singha, S.; Sunoj, R. B.; Maiti, D.

    Chem. Sci. 20167, 3147-3153

 Remote para-C-H Functionalization of Arenes by a D-Shaped Biphenyl Template-Based Assembly


    Bag, S.; Patra, T.; Modak,A.; Deb, A.; Maity, S.; Dutta, U.; Dey, A.; Kancherla, R.; Maji, A.; Hazra, A.; Bera, M.; Maiti, D.
    J. Am. Chem. Soc. 2015, 137, 11888-11891
This work is highlighted in JACS Spotlight 

 Pd(II)-Catalyzed meta-C-H Olefination: Constructing Multi-substituted Arenes through Homo-diolefination and Sequential Hetero-diolefination


    Bera, M; Maji, A.; Sahoo, S. K.; Maiti, D. 
    Angew. Chem. Int. Ed. 201554, 8515-8519

 Palladium Catalyzed Aryl C-H Olefination with Unactivated, Aliphatic Alkenes


    Deb, A.; Bag, S.; Kancherla, R.; Maiti, D. 
    J. Am. Chem. Soc. 2014, 136, 13602-13605 
(Most Read Article)

 Palladium-Catalyzed Annulation of Diarylamines with Olefins through C-H Activation

Direct Access to N-Arylindoles


    Sharma, U.; Kancherla, R.; Naveen, T.; Agasti, S.; Maiti, D. 
    Angew. Chem. Int. Ed. 201453, 11895-11899 
(Most read article)

 Synthesis of Bis-heteroaryl Ketones via Removal of Benzylic -CHR- and -CO- Groups


   Maji, A.; Rana, S.; Akanksha and Maiti, D. 
   Angew. Chem. Int. Ed. 2014, 53, 2428-2432

 Palladium-Catalyzed Synthesis of Benzofurans and Coumarins from Phenols and Olefins.


      Sharma, U.; Togati, N.; Maji, A.; Manna, S.; and Maiti, D. 

      Angew. Chem. Int. Ed. 2013, 52, 12669-12673

 Oxidative Trifluoromethylation of Unactivated Olefins: An Efficient and Practical Synthesis of α-Trifluoromethyl Ketones.


       Deb, A.; Manna, S.; Modak, A.; Patra, T.; Maity, S.; Maiti, D. 
       Angew. Chem. Int. Ed. 2013, 52, 9747-9750

 Efficient and Stereoselective Nitration of Mono- and Disubstituted Olefins with AgNO2 and TEMPO


      Maity, S.; Manna, S.; Rana, S.; Togati, N.; Mallick, A; Maiti, D.   
      J. Am. Chem. Soc. 2013, 135, 3355-3358

     This paper was highlighted in Synthesis 2013, 45, A82-A84

     Invited article in Synlett as Synpacts

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